Dynamics of the Drosophila circadian clock: theoretical anti-jitter network and controlled chaos.

Dynamics of the Drosophila circadian clock: theoretical anti-jitter network and controlled chaos.

Blog Article

BACKGROUND: Electronic clocks exhibit undesirable jitter or time variations in periodic signals.The circadian clocks of humans, some animals, and plants consist of oscillating molecular networks with peak-to-peak time of approximately 24 hours.Clockwork orange (CWO) is a transcriptional repressor of Drosophila direct target genes.

METHODOLOGY/PRINCIPAL FINDINGS: Theory and data from a model of the Drosophila circadian clock support the idea that CWO controls anti-jitter negative circuits that stabilize peak-to-peak time in wella color charm 050 cooling violet light-dark cycles (LD).The orbit is confined to chaotic attractors in both LD and dark cycles and is almost periodic in LD; furthermore, CWO diminishes the Euclidean dimension of the chaotic attractor in LD.Light resets the clock each day by restricting each molecular peak to the proximity ealisboa.com of a prescribed time.

CONCLUSIONS/SIGNIFICANCE: The theoretical results suggest that chaos plays a central role in the dynamics of the Drosophila circadian clock and that a single molecule, CWO, may sense jitter and repress it by its negative loops.